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GHK-Cu is generally well-tolerated in preclinical and early research settings
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In murine models of inflammatory arthritis, liraglutide treatment significantly reduced synovial inflammation, joint damage, and the expression of cytokines such as TNF-α and IL-1β, likely mediated through GLP-1R expressed on macrophages and fibroblast-like synoviocytes within the inflamed joint microenvironment [368–370]
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