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However, polyunsaturated PLs are inherently unstable due to the weak -O-O bond energy of GPL-OOH and readily undergo secondary free radical reactions, giving way to numerous truncated reactive products, including electrophilic oxidatively truncated lipids (epoxy/keto/hydroxy-lipids), or short leaving fragments without the signatures of parental phospholipid identity, such as 4-hydroxynonenal (4-HNE), 4-oxononenal, acrolein and malondialdehyde (MDA) etc [28]
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