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CII present in cartilages of different animals might not have to vary distinguished amino acid composition, for instance, the triple-helical region of CII in mice had substituted only 13 out of 1015 amino acids compared to rats [50,51], which even might be due to the extensive post-translational modifications such as glycosylation of hydroxylysines and hydroxylation of lysines and prolines

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These findings are consistent with clinical observations from practitioners who report visible improvements in wound healing within the first one to two weeks of treatment