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Paciente com história prévia de reações cutâneas a metais — embora reações ao cobre injetável sejam raras na literatura disponível —, paciente com pele com sinais de barreira comprometida, paciente em uso de anticoagulantes ou antiagregantes plaquetários, paciente em fase aguda de inflamação cutânea ou em período pós-procedimento recente, paciente gestante ou em amamentação: todos esses cenários ajustam o limiar de intervenção para cima e podem contraindicar formalmente o procedimento
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Finally, some polymers, such as polyacrylic acid, alginates and hyaluronic acid, adhere by physically entangling with mucin fibres and are commonly used for mucoadhesive particles coatings 62,143
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