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Therefore, elevated concentrations of GHB, detected in SSADH deficient neurons, are highly cytotoxic and are associated with a rare (1:460,000) autosomal recessive condition SSADHD (SSADH deficiency) [193]
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These findings underscore the unique pathological timeline and molecular changes in the TgAPParc model, providing a valuable tool for studying Alzheimer’s disease pathogenesis and therapeutic development
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