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Cytokines such as IFN-γ, CXCL9, and CXCL10 recruit cytotoxic T cells to skin lesions, exacerbating oxidative stress and inducing ferroptosis in melanocytes (130)

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2, 3 The first is the direct exchange of information between the gut and the brain through neuroanatomical approach, exchanging information directly between the intestinal tract and brain by the VN, the pelvic splanchnic nerve and some branches of the sympathetic nerve in the spinal cord, and also through the neuroendocrine system, such as the HPA-axis based on the evidence that plasma ACTH and corticosterone concentrations in germ-free mice were significantly increased in response to stress inhibition compared with specific pathogen-free mice