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"These findings support a potential new therapeutic tool to effectively improve HbA1c levels well below 7% in such a challenging population of inadequately controlled basal insulin-treated type 2 diabetes with the benefit of substantial weight loss, no increase of hypoglycemia risk, and without having to increase insulin doses," said Julio Rosenstock, MD, lead author of the REIMAGINE 3 study.¹ "As we look to provide more solid options for people with type 2 diabetes beyond insulin-based therapies, it's also important to note the safety and tolerability profile was consistent with previous GLP-1 RA trials." "Rather than focusing on glucose control alone, this strategy addresses weight, cardiovascular risk, and metabolic health together, with the goal of preventing long-term complications and, for some people, fundamentally resetting the trajectory of diabetes itself," said Vanita Aroda, MD, lead author of REIMAGINE 1.¹ References American Diabetes Association

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Regulation of 4-hydroxynonenal mediated signaling by glutathione S-transferases