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Unlike most peptides of comparable length it is notably stable in aqueous solution and resists degradation in low-pH conditions, which is the property that first made it attractive to laboratory investigators and the reason it is handled as a straightforward reagent rather than a fragile one.\n\nIn preclinical models the compound is studied chiefly for its interaction with angiogenic signaling — VEGFR2 pathway activation and downstream nitric-oxide system involvement — and for effects on focal adhesion kinase and paxillin signaling in fibroblast migration assays