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Cysteine crosslinking suggests that Cys243 in TM4 and Cys306 at the extracellular end of TM6 contribute to the oligomeric interface of hDAT dimers and higher order oligomers (Hastrup et al., 2001

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On that test, an NNMT inhibitor plus an NAD+ precursor is at least internally coherent — one addresses the drain, the other the supply — while pairing 5-Amino-1MQ with an unrelated appetite-acting compound is not “synergy,” it is simply two separate interventions being run at once