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Probiotic therapy also reduced inflammatory markers such as TNF-α, IL-1β, IL-4, and IL-12 734

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Liver transplantation in AIP patients with severe recurrent attacks If the standard treatment is unsuccessful or quality of life is unbearable, liver transplantation is an option for severely affected patients.24,49 Currently, more than ten AIP patients have undergone liver (or liver-kidney) transplantation since 2004.24,49,76 It has been successful in the majority of cases resulting in immediate correction of abnormal porphyrin metabolism and cessation of attacks and chronic pain syndrome.24 Immunosuppressive drugs have been tolerated well by the patients, and their quality of life has improved dramatically

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