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[5] Use of Lipo-C Injection is contraindicated in patients with known hypersensitivity to methionine, choline salts, carnitine, dexpanthenol, or any formulation excipients, as well as in individuals with severe hepatic failure in whom augmented methionine intake could precipitate hypermethioninemia and encephalopathy

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Eight-fold increased risk for congenital heart defects in children carrying the nicotinamide N-methyltransferase polymorphism and exposed to medicines and low nicotinamide