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This ensemble of experimental evidence mechanistically establishes that inherent photodegradation reduces the antibacterial activity of tigecycline and minocycline in solution-phase systems because of the structural vulnerability of their D-ring dimethylamino moieties, with degradation pathways directly correlated with the loss of antimicrobial efficacy

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11 , 12 , 13 Several studies have demonstrated that erythrocytes, serum, and cerebrospinal fluid (CSF) levels of glutathione (GSH), a vital antioxidant, are reduced in MS patients