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This effect is linked to dramatic oxidation and accumulation of glutathione in cat2 gr1 , while the gr1 mutation is associated with compromised responses to pathogens and altered expression of genes involved in defense hormone signaling (Mhamdi et al., 2010a)
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This review aims to fill this gap, collate and discuss the aforementioned parameters, i.e., the genetic basis and consequent pathophysiology of different types of haemochromatosis in one article to enable and enhance the understanding of this genetic iron disorder in both researchers and prospective medics
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