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During C2C12 myoblast differentiation, mitophagy is induced in the early stage of myogenesis to clear preexisting mitochondria and make way for newly generated OXPHOS-competent mitochondria from a burst of mitochondrial biogenesis [58]
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In agreement, pharmacological (by SFN) or genetic (by Keap1 knockdown) upregulation of Nrf2 in human nontumorigenic breast epithelial MCF10A cells causes increases in the PPP enzymes [36]
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