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A widely used appetite-suppressing weight-loss drug may be contributing to vitamin deficiencies — including a disease historically associated with 18th-century sailors.

Animal studies tell us something might work and provide clues about how it works

Regenerative Research

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Indeed, we found that expression of Ox2r and Prdm13 , two downstream genes in the SIRT1-mediated signaling pathway in the hypothalamus, exhibited significant decreases in the hypothalami of 300 mg/kg/day NMN-treated mice (our preliminary finding), which could partly explain some of the observed differences in the effects of NMN, particularly those on physical activity, between two tested doses