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The UKALL2003 (NCT00222612) study demonstrated that reduction of therapy (i.e., one rather than two courses of delayed intensification) did not adversely impact outcome in non-high–risk patients with favorable EOI MRD.[22][Level of evidence B1] In a randomized controlled trial, the UKALL2003 study also demonstrated improved EFS for standard-risk and intermediate-risk patients who received augmented therapy if EOI MRD was greater than 0.01% (5-year EFS rates, 89.6% for augmented therapy vs

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doi: 10.1186/1742-2094-8-105