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While these gain- and loss-of-function experiments have helped reveal the myriad of roles of Wnt/β-catenin signaling during development of the vestibular organs, it is important to point out that the levels of Wnt signaling also critically regulate morphogenesis as both inhibiting and activating modulators lead to a malformed vestibular system (Stevens et al., 2003)

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doi:10.1097/JU.0000000000001703 Kurniawan AL, Hsu C-Y, Rau H-H, Lin L-Y, Chao JCJ