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You should seek medical advice if you experience: Persistent constipation that is not improving after trying self-care measures for a few weeks Blood in your stools (either bright red or dark, tar-like stools) Unexplained weight loss accompanying bowel changes Severe abdominal pain or bloating that is worsening or persistent Alternating constipation and diarrhoea that is persistent or recurrent A significant change in your normal bowel pattern, particularly if you are aged 60 or over with change to looser or more frequent stools, or aged 50 or over with unexplained rectal bleeding Symptoms of bowel obstruction such as inability to pass wind, severe cramping, or vomiting According to NICE guidance , these features may indicate conditions requiring investigation, including colorectal cancer, inflammatory bowel disease, or other gastrointestinal disorders

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However, it should be noted that of the 13 studies, only seven focused solely on GSH reproducibility along with other low signal metabolites, specifically the 4T study (Terpstra et al., 2005), half (3/6) of the 3T studies (Prisciandaro et al., 2020, Wijtenburg et al., 2014, Wijtenburg et al., 2019), and three 7T studies (Gonen et al., 2020, Lally et al., 2016, Prinsen et al., 2017)