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Retatrutide's receptor potency profile is GIP-primary: EC50 values are 0.0643 nM at the GIP receptor (most potent), 0.775 nM at GLP-1, and 5.79 nM at glucagon
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They bind to receptors on cells and trigger a range of biological effects, from the regeneration of tissue to the production of hormones — making them an increasingly important class of drugs
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