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Selective KOR engagement can profoundly influence neuronal excitability, synaptic transmission, sensory integration, large-scale brain network connectivity, and subjective experience [22,42,43]
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Common side effects of hydroxycobalamin may include • Nausea • Vomiting • Diarrhea • Headache • Dizziness • Memory problems • Restlessness • Stomach pain • Acne • Skin rash or itching • Red coloring of skin or urine (this may last up to 2 to 5 weeks) • Warmth or redness under your skin • Dry throat • Trouble swallowing • Hot flashes, • Injection site reactions (pain, swelling, or irritation of skin), or • Eye redness or irritation [15]
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