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In molecular docking models, it has been observed that curcumin fits into the active site of histone deacetylase HDAC8, forming contacts with residues Arg37, Pro35, Ile34, and Phe152 of the catalytic pocket

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Precisely at the core of the central gain model is the hypothesis that extensive spontaneous and sound-evoked neuronal hyperactivity in higher auditory structures (e.g., DCN) may constitute a key neural correlate underlying the sound percepts of tinnitus 46,47,48,49