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In consequence, there is limited redox cycling of the active drug metabolite and they are less susceptible to drug-induced methaemoglobinaemia, but they are more susceptible to haemolysis (see below)

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Management Plan: Lifestyle Modification Refer to a registered dietitian for Mediterranean diet counseling Encourage at least 150 minutes/week of moderate-intensity exercise (e.g., brisk walking) Enroll in a structured weight loss program Stress management support: mindfulness, counseling referral Pharmacologic Therapy Initiate statin therapy per 2023 AHA/ACC guidelines Begin antihypertensive (ACE inhibitor or ARB, titrated as needed) Consider starting low-dose aspirin based on risk calculation Monitor for diabetes progression