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AIF is not dependent on functional caspases and could, therefore, serve as an alternative death pathway after cellular energy depletion (Broughton et al., Glial Cells and Apoptosis Neurons and cells of the oligodendroglial lineage are the most sensitive cellular elements and are damaged on the front line of ischemia or later they undergo delayed cell death
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Correlating with the degree of demyelination, astrogliosis is increasing during acute demyelination peaking around the time point of maximal demyelination and incipient remyelination around 5–6 weeks of cuprizone exposure (Hiremath et al., 1998
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