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This complex, which acts as the primary transcriptional activator, efficiently initiates the transcription of various clock‐controlled genes, including the Per and Cry genes, by binding to E‐box elements in their promoter regions [20, 21]
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CLD encompasses viral hepatitis, alcoholic liver disease (ALD), autoimmune hepatitis, NAFLD, NASH, and cholestatic liver diseases, among others [41–43]
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