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Contrary to previous studies, interestingly, it was observed that NOR upregulation in the DRGs in NP animal models with partial sciatic nerve transection and sciatic nerve ligation [75,126] may increase the analgesic properties of endogenous ligand nociceptin under NP conditions without the opioid-related side effects [127]
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Interestingly, these differences in vitamin B12 levels were further enlarged with increased age [179]
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