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Aldosterone’s Role • Acts on distal tubules and collecting ducts of the kidney to increase: • Na⁺ reabsorption • Water retention • K⁺ excretion • This raises blood volume and blood pressure
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Administration of low doses of leptin in humans after weight loss has been shown to reverse these counter-regulatory neuroendocrine responses and increase energy expenditure, thus maintaining the weight reduction [40,44]
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