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At the molecular level, functional foods rich in such antioxidants as polyphenols and flavonoids help reduce oxidative stress by neutralising ROS- and NO-dependent pathways, while exercise induces controlled oxidative stress that activates adaptive pathways [182]
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Although not definitively causal, these findings support the biological concern that exogenous antioxidants may attenuate ROS-mediated cytotoxic mechanisms induced by chemotherapy and radiotherapy, potentially reducing treatment efficacy
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