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Studies in vitro on neurons showed that dopamine can lead to apoptosis through mitochondrial dysfunction, reduce cellular ATP, and cause impairment of mitochondria via inhibition of complex I [147]
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Importantly, when polyphenols and topoisomerase II inhibitors were combined, it was possible to induce a synergistic decrease in cell proliferation (measured as ATP levels), cell-cycle arrest and induction of apoptosis in leukaemia cell lines
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