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Thus, the scarce human studies performed so far, regardless of all of the limitations in some of them (i.e., they lacked a large sample size, ethnic variation, and a sham control group), encompassed a wide range of investigations (i.e., ulcerative colitis [65], knee pain [263], and interstitial cystitis [264])

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TB500: Chemically designed fragment (typically the first 43 amino acids of the Tβ4 protein) optimized for stability and bioavailability for research purposes