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Telomeres and Aging | LIVV Natural

Not everyone gets that side effect, but enough people do that it should be anticipated and discussed

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Documented effects include: Upregulation of SOD1 (cytosolic Cu/Zn-SOD), CAT (catalase), and GPX1 (glutathione peroxidase 1) mRNA and protein in multiple cell types NRF2 nuclear translocation and ARE-driven gene induction (HO-1, NQO1, GCLC, TXNRD1) Reduction of 4-hydroxynonenal (4-HNE) adducts and 8-hydroxy-2′-deoxyguanosine (8-OHdG) — markers of lipid peroxidation and oxidative DNA damage respectively Mitochondrial ROS reduction via Complex IV cuproenzyme enhancement (cytochrome c oxidase activity assay) Epitalon’s antioxidant activity is primarily documented via melatonin restoration (melatonin is itself a potent radical scavenger) and through modest upregulation of SOD and catalase in aged rodent tissues — a secondary effect rather than a primary mechanism