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Using a training model to decode complex features (texture, shape, etc.) in CT images, key metabolic phenotypes, such as PLIN2 expression and ferroptosis sensitivity, can be predicted, and patients with “high-risk” metabolic characteristics (such as DCCD tendency) can be identified before treatment ( 4 Treatment opportunities: from pathway to scheme 4.1 Treatment strategies for directly targeting metabolic pathways Hypoxic axis: With the emergence of the HIF-2α inhibitor belzutifan, the hypoxia-driven metabolic–angiogenic program can be pharmacologically inhibited for the first time

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