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TRPV1 is expressed in about 60% of vagal neurons, and TRPA1 in about 25%.[ref] In addition to chemical stimuli, TRP receptors respond to oxidative stress and systemic inflammation.[ref] Repeated activation and hyperexcitability: TRPA1 and TRPV1 receptors are often co-localized on the same cells

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For example, mutant p53 can induce noncanonical NF‒κB (NC‒NF‒κB) signaling through the cGAS‒STING pathway, which promotes tumor cell invasion, metastasis, and immunosuppression