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Unrestrained replication fork progression in oncogene-expressing cells defective in fork reversal is mediated by PRIMPOL Recent work has shown that the restart of R-loop-stalled forks via the MUS81-LIG4-ELL axis also requires the DNA primase-polymerase PRIMPOL 14 , which is known to mediate repriming of DNA synthesis downstream of DNA lesions that block replication fork progression 38,39,40
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Fulfillment Location:France
J Biol Chem 272 :11369–11377
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