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Recently, natural products such as (−)-epigallocatechin-3-gallate (EGCG), Centella asiatica (CA), ginkgolides, quercetin (Que), berberine (BBR), and curcumin have demonstrated anti-hypoxic neurological injury effects in animal and cellular models by modulating hypoxia-inducible factor 1 alpha (HIF-1α), inhibiting oxidative stress, attenuating neuroinflammation, and decreasing apoptosis, among other activities
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