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The results of this 1981 double-blind placebo-controlled study with 20 human volunteers showed that DMG enhances humoral and cell-mediated immune response in humans.* The researchers presumed DMG had potential as an immunomodulator because of studies done on calcium pangamate.* The study proved that the test group taking DMG had a greater than fourfold increase in antibody response to the pneumococcal vaccine as compared to the control group.* The DMG group also had a significantly higher overall response of leukocyte streptokinase-streptodornase, showing that it enhances the cell-mediated response as well.* Researchers conducted a study in 2015 to investigate N, N Dimethylglycine, and its association with insulin resistance and metabolic traits using mass spectrometry-based metabolic approaches.* Results showed consistent data points to the possibility of DMG deficiency playing a causal role in insulin resistance development

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Kornblau SM, Ruvolo P, Wang RY, Ruvolo V, Qui YH, Battula VL, Zeng Z, McQueen T, Yoo SY, Konopleva M, and Andreeff M