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The trillions of microorganisms residing in the gastrointestinal tract produce a wide range of metabolites, including SCFAs, neurotransmitters, and other bioactive molecules, which influence brain function and behavior through multiple pathways ( Table 1 )
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Therefore, considering a broad spectrum of effects that may result from the induction of NO synthesis, a deep analysis of its interaction with potent drugs affecting NO pathways should be performed (e.g., aspirin that has been shown to inhibit eNOS [57])
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