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Elevated levels of PARP-1 following an IS initiate the movement of apoptosis-inducing factor (AIF) into the nucleus, leading to breakdown of chromatin and cell death independent of caspase activation via binding to the histone variant H2A histone family member X (H2AX) (46, 47)

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Mario Knezevic, Departments of Pharmacology and Pathology, Medical Faculty University of Zagreb, Zagreb 10000, Croatia