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Regarding feeding behavior, 3xTg mice consume more food with a rise in metabolic rate as compared to non-transgenic controls (Knight et al., 2012), and the increased feeding could be attributed to defective brain responses to endogenous satiety factors released by food ingestion (Romberg et al., 2011)
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Cytochrome c binds to apoptosis protease activating factor 1 (APAF1) in the cytoplasm, and together, they activate caspase 9
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