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Their findings revealed a significant reduction in glucose production and expression of both G6pc and Pck1 in hepatocytes with NNMT overexpression and concurrent Sirt1 inhibition, compared to hepatocytes with NNMT overexpression alone
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No large-scale human RCTs for BPC-157 have been published as of 2024, making efficacy claims in people unsupported by the gold standard of clinical evidence
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