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Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of the cellular antioxidant response, which regulates the expression of genes associated with both antioxidant defense and iron metabolism, such as heme oxygenase-1 (HO-1), ferritin heavy chain (FTH1), and solute carrier family 7 member 11 (SLC7A11) (Przybyszewska and Zekanowska, 2014
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