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Various studies reported significant increase in GSHPX and GST, whereas decrease in GSH and total glutathione levels in gingival tissues and serum from an experimental group (periodontitis patients) when compared to the control group (periodontally healthy patients) [Table 5].[28,57,90,92,103] Peripheral blood neutrophils from chronic periodontitis patients have more GSSG level relative to GSH as compared to neutrophils from healthy control subjects
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The hydroxy and methyl groups of the isohexenyl side chain of the shikonin tail form hydrogen bonds with R188 and Q189, respectively, in the S3 subsite
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