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GLP-2 further inhibits NF-κB signaling to reduce pro-inflammatory cytokines, such as TNF-α and IL-6, prevents inflammation-induced submucosal ganglion neuron loss, and increases vasoactive intestinal peptide-positive (VIP + ) neuron proportions, collectively repairing neuroinflammatory damage (Hiramoto et al., 2024) indicates GLP-1RAs delay solid-phase gastric emptying by approximately 36 minutes, yet without statistically significant effects on liquid-phase emptying
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increased corneal nerve fiber density Study Type 2 diabetes (2014) Design 4 mg subQ daily, 28 days Key result Improved neuropathic symptoms, HbA1c, lipids, nerve density Study Phase 2b sarcoidosis (2017) Design 64 patients, 1/4/8 mg subQ daily, 28 days Key result Met primary corneal nerve-regeneration endpoint
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