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PD and several related neurodegenerative disorders can also been considered as proteinopathies, in which the core neurodegeneration of nigrostriatal dopaminergic neurons in PD is also associated with a more widespread cellular deposition of alpha-synuclein 8
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Dose Titration We start patients at a conservative dose and titrate upward over the first 8 to 12 weeks based on response and tolerance
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